ERH

Across TCGA patient cohorts, ERH mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERH-associated genes across cancer lineages are MED28P4, ARPP19P1, and OR6R2P. Each is linked with ERH in more than 1 cancer types. Because this analysis shows association rather than direction, both ERH-to-partner and partner-to-ERH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED28P4 grouped by ERH-low versus ERH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERH→partner) and Y-score (partner→ERH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED28P4 →	+0.344	+3.960	<.001	.007	3	2
UCEC	ARPP19P1 →	+0.229	+4.003	.002	.005	3	2
UCEC	OR6R2P →	+0.612	+4.061	<.001	.005	3	1
UCEC	MIR6795 →	+0.578	+6.475	<.001	<.001	3	1
SKCM	ELOAP1 →	+0.023	+7.485	<.001	<.001	3	1
SKCM	MTCO2P23 →	+0.074	+6.624	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MED28P4 by ERH expression — UCEC

Explore this box plot interactively →