ERGIC1

Across TCGA patient cohorts, ERGIC1 mutation is significantly associated with the RNA expression of many other genes, with 718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERGIC1-associated genes across cancer lineages are SRIP2, STSP1, and MIR521-2. Each is linked with ERGIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERGIC1-to-partner and partner-to-ERGIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRIP2 grouped by ERGIC1-low versus ERGIC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERGIC1→partner) and Y-score (partner→ERGIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SRIP2 →	+0.175	+4.358	<.001	<.001	3	2
SKCM	STSP1 →	+0.021	+3.680	<.001	.003	3	2
BRCA	MIR521-2 →	+0.271	+8.055	<.001	.007	3	2
BRCA	MIR1197 →	+0.396	+7.731	<.001	.009	3	2
UCEC	TANGO2 →	+0.387	+2.673	.002	<.001	3	2
UCEC	RNA5SP410 →	+0.662	+2.526	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 718 associations by consensus.

SRIP2 by ERGIC1 expression — SKCM

Explore this box plot interactively →