ERGIC1

Across TCGA pan-cancer cohorts, ERGIC1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ERGIC1 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ERGIC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERGIC1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LGG, LUAD, and HNSC are the cancer types where ERGIC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.674	0.808	<.001	54	view →
LUAD	DFS	Quartile	III,IV	0.340	0.804	<.001	48	view →
HNSC	OS	Tertile	All	0.270	0.632	<.001	44	view →
LUSC	OS	Quartile	All	0.280	0.570	.001	44	view →
CESC	DFS	Quartile	All	0.732	0.894	<.001	42	view →
KIRC	DFS	Tertile	All	0.851	0.702	.004	42	view →
UVM	OS	Tertile	III,IV	0.640	0.940	.002	36	view →
BLCA	DFS	Tertile	All	0.213	0.583	<.001	34	view →
SCLC	OS	Tertile	II,III,IV	0.257	0.654	.004	23	view →
MESO	OS	Quartile	All	0.367	0.638	.011	21	view →
LIHC	DFS	Quartile	All	0.468	0.664	.004	19	view →
READ	OS	Tertile	All	0.938	0.492	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ERGIC1–LGG (DFS)

Open the LGG breakdown →