ERFE

Across TCGA patient cohorts, ERFE mutation is significantly associated with the RNA expression of many other genes, with 685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERFE-associated genes across cancer lineages are NF1P5, RNU4-45P, and GYG2P1. Each is linked with ERFE in more than 1 cancer types. Because this analysis shows association rather than direction, both ERFE-to-partner and partner-to-ERFE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P5 grouped by ERFE-low versus ERFE-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERFE→partner) and Y-score (partner→ERFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NF1P5 →	+0.077	+5.144	<.001	.003	3	1
CESC	RNU4-45P →	+0.227	+5.342	<.001	.002	3	1
CESC	GYG2P1 →	+0.028	+4.601	<.001	.004	3	1
CESC	RNU6-514P →	+0.520	+4.409	<.001	.006	3	1
CESC	MIR549A →	+0.336	+5.342	<.001	.002	3	1
CESC	MIR550A3 →	+0.434	+4.364	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 685 associations by consensus.

NF1P5 by ERFE expression — CESC

Explore this box plot interactively →