ERFE

Across TCGA pan-cancer cohorts, ERFE RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ERFE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ERFE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERFE is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where ERFE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERFE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.306	<.001	12	view →
COAD	All	III,IV	+1.626	<.001	11	view →
LUAD	Male	II,III,IV	+1.443	<.001	10	view →
LUSC	Male	II,III,IV	+1.281	<.001	9	view →
STAD	Female	All	+1.140	<.001	9	view →
KIRC	Male	III,IV	−1.081	<.001	9	view →
LIHC	Female	All	+0.758	<.001	8	view →
UCEC	All	II,III,IV	+2.717	<.001	6	view →
BLCA	Male	All	+0.879	.003	6	view →
BRCA	All	II,III,IV	+0.405	<.001	6	view →
KICH	Female	All	−1.805	<.001	5	view →
ESCA	All	II,III,IV	+1.805	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ERFE–HNSC

Open the HNSC breakdown →