ERCC2

Across TCGA patient cohorts, ERCC2 mutation is significantly associated with the RNA expression of many other genes, with 2,242 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC2-associated genes across cancer lineages are TRAJ21, ALAS1, and FANCD2. Each is linked with ERCC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ21 grouped by ERCC2-low versus ERCC2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	TRAJ21 →	+0.557	+4.721	<.001	.007	3	3
UCEC	ALAS1 →	+0.521	+3.708	.002	<.001	3	3
UCEC	FANCD2 →	+0.654	+3.721	<.001	<.001	3	3
COAD	PGAM1P6 →	+0.200	+4.011	.008	.001	3	3
LIHC	OR6R2P →	+0.146	+3.481	<.001	.008	3	2
BRCA	RNA5SP147 →	+0.247	+5.324	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,242 associations by consensus.

TRAJ21 by ERCC2 expression — PRAD

Explore this box plot interactively →