EQTN

Across TCGA cell cohorts, EQTN mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EQTN-associated genes across cancer lineages are PRAMEF12, HTR1E, and OR52N5. Each is linked with EQTN in more than 1 cancer types. Because this analysis shows association rather than direction, both EQTN-to-partner and partner-to-EQTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF12 grouped by EQTN-low versus EQTN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EQTN→partner) and Y-score (partner→EQTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF12 →	+0.051	+3.977	<.001	.001	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR52N5 →	+0.045	+4.022	<.001	.006	3	1
LARGE_INTESTINE	FAM205C →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.285	+3.722	<.001	.007	3	1
LARGE_INTESTINE	DNASE1L3 →	+0.159	+3.491	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRAMEF12 by EQTN expression — LARGE_INTESTINE

Explore this box plot interactively →