EPHA8

Across TCGA patient cohorts, EPHA8 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,196 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EPHA8-associated proteins across cancer lineages are ZNF638_S128, CACNA2D2, and HDLBP. Each is linked with EPHA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA8-to-partner and partner-to-EPHA8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPHA8 versus ZNF638_S128 in LSCC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA8→partner) and Y-score (partner→EPHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF638_S128 →	+0.416	+0.326	<.001	.001	3	3
GBM	CACNA2D2 →	+0.713	+0.200	<.001	<.001	3	3
LSCC	HDLBP →	-0.299	-0.277	<.001	.001	3	3
GBM	ARFGAP3 →	-0.276	-0.145	<.001	<.001	3	3
BRCA	SND1 →	-0.227	-0.551	.001	.002	3	3
PDAC	MYO9B_S1290 →	-0.606	-0.267	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,196 associations by consensus.

EPHA8 vs ZNF638_S128 — LSCC

Explore this scatter interactively →