EPHA8

Across TCGA pan-cancer cohorts, EPHA8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EPHA8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EPHA8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EPHA8 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, BRCA, and LUSC are the cancer types where EPHA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPHA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.238	.001	8	view →
BRCA	Female	All	+0.448	<.001	6	view →
LUSC	All	II,III,IV	+0.123	.003	4	view →
UCEC	All	II,III,IV	+0.081	.035	4	view →
COAD	All	II,III,IV	+0.063	.015	4	view →
THCA	Male	III,IV	−0.081	.009	3	view →
LUAD	Female	II,III,IV	+0.039	.015	3	view →
PAAD	Male	All	+0.995	.004	2	view →
PRAD	All	All	+0.359	<.001	2	view →
KIRC	Female	II,III,IV	−0.028	.030	2	view →
KIRP	Male	All	−0.032	.001	1	view →
CHOL	All	All	+0.031	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EPHA8–HNSC

Open the HNSC breakdown →