EPHA8

Across TCGA pan-cancer cohorts, EPHA8 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated EPHA8 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPHA8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EPHA8 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUAD show a favorable association.

KIRC, UVM, and LIHC are the cancer types where EPHA8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.507	0.732	<.001	174	view →
UVM	DFS	Median	All	0.416	0.739	<.001	136	view →
LIHC	OS	Quartile	All	0.541	0.728	<.001	57	view →
SKCM	OS	Tertile	All	0.290	0.536	<.001	41	view →
THYM	DFS	Quartile	III,IV	0.226	1.000	.001	40	view →
OV	OS	Quartile	III,IV	0.807	0.912	.003	28	view →
ACC	DFS	Quartile	III,IV	0.241	0.766	.010	21	view →
SCLC	OS	Median	II,III,IV	1.000	0.462	.005	15	view →
THCA	DFS	Quartile	III,IV	0.628	0.906	.003	15	view →
LUAD	OS	Quartile	All	0.794	0.578	.006	14	view →
UCEC	DFS	Median	All	0.860	0.932	.001	12	view →
GBM	OS	Quartile	All	0.356	0.544	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

EPHA8–KIRC (OS)

Open the KIRC breakdown →