EPHA8

Across TCGA patient cohorts, EPHA8 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA8-associated genes across cancer lineages are STAT3_pY705, Fibronectin, and AMPK_alpha. Each is linked with EPHA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA8-to-partner and partner-to-EPHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by EPHA8-low versus EPHA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA8→partner) and Y-score (partner→EPHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.296	-1.688	<.001	.001	3	3
STAD	Fibronectin →	+0.353	+3.480	.021	.002	3	2
STAD	AMPK_alpha →	-0.170	-2.321	.025	.034	3	2
STAD	c-Kit →	-0.343	-3.169	.016	.017	3	2
LUSC	FOXO3a_pS318_S321 →	-0.138	-3.557	.012	.002	3	2
UCEC	MEK1 →	+0.316	+1.999	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

STAT3_pY705 by EPHA8 expression — UCEC

Explore this box plot interactively →