EPHA8

Across TCGA cell cohorts, EPHA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 812 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible EPHA8-associated GO terms across cancer lineages are Positive regulation of cation transmembrane transport, Positive regulation of monoatomic ion transmembrane transport, and Protein-RNA complex organization. Each is linked with EPHA8 in more than 8 cancer types. Because this analysis shows association rather than direction, both EPHA8-to-partner and partner-to-EPHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cation transmembrane transport grouped by EPHA8-low versus EPHA8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA8→partner) and Y-score (partner→EPHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of cation transmembrane transport →	-0.082	-0.382	<.001	.003	3	9
BREAST	Positive regulation of monoatomic ion transmembrane transport →	-0.085	-0.341	<.001	.008	3	9
OESOPHAGUS	Protein-RNA complex organization →	+0.075	+0.620	<.001	.005	3	7
OESOPHAGUS	Purine nucleoside triphosphate biosynthetic process →	+0.092	+0.611	.002	.006	3	7
OESOPHAGUS	Purine ribonucleoside triphosphate biosynthetic process →	+0.092	+0.611	.002	.006	3	7
SOFT_TISSUE	Calcium ion transport →	-0.037	-0.203	.003	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 812 associations by consensus.

Positive regulation of cation transmembrane transport by EPHA8 expression — BREAST

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