EPHA8

Across TCGA cell cohorts, EPHA8 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA8-associated genes across cancer lineages are DUSP29, COX11, and NLRP8. Each is linked with EPHA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA8-to-partner and partner-to-EPHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUSP29 grouped by EPHA8-low versus EPHA8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA8→partner) and Y-score (partner→EPHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DUSP29 →	+0.052	+4.930	.005	.008	3	2
LARGE_INTESTINE	COX11 →	+0.751	+3.502	<.001	.001	3	2
BLOOD_Leukemia	NLRP8 →	+0.026	+3.464	.002	.003	3	2
LUNG_NSCLC_LUAD	OR13C8 →	+0.021	+4.078	<.001	.009	3	2
OESOPHAGUS	RHO →	+0.049	+3.201	<.001	.003	3	1
OESOPHAGUS	VWC2 →	+0.045	+2.857	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

DUSP29 by EPHA8 expression — SOFT_TISSUE

Explore this box plot interactively →