EPB42

Across TCGA patient cohorts, EPB42 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB42-associated genes across cancer lineages are Caspase-8, FoxM1, and MEK1. Each is linked with EPB42 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPB42-to-partner and partner-to-EPB42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by EPB42-low versus EPB42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB42→partner) and Y-score (partner→EPB42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.252	-2.392	.004	<.001	3	2
UCEC	FoxM1 →	+0.181	+1.362	.048	.037	3	2
UCEC	MEK1 →	+0.408	+2.000	.001	.003	3	2
UCEC	Annexin_VII →	-0.104	-1.662	.034	.011	3	2
UCEC	14-3-3_beta →	-0.100	-1.986	.005	.003	3	1
UCEC	eEF2 →	+0.424	+2.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-8 by EPB42 expression — UCEC

Explore this box plot interactively →