EPAS1

Across TCGA patient cohorts, EPAS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,839 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EPAS1-associated proteins across cancer lineages are LAMA4, PLVAP, and CDH5. Each is linked with EPAS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both EPAS1-to-partner and partner-to-EPAS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPAS1 versus LAMA4 in OV, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EPAS1→partner) and Y-score (partner→EPAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMA4 →	+0.749	+1.264	<.001	<.001	3	7
CCRCC	PLVAP →	+0.828	+0.885	<.001	<.001	3	7
CCRCC	CDH5 →	+0.591	+1.012	<.001	<.001	3	6
OV	PUS1 →	-0.598	-1.258	<.001	<.001	3	5
BRCA	STRAP →	-0.213	-0.953	.005	<.001	3	5
CCRCC	MMRN2 →	+0.809	+1.027	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,839 associations by consensus.

EPAS1 vs LAMA4 — OV

Explore this scatter interactively →