EPAS1

Across TCGA pan-cancer cohorts, EPAS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EPAS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EPAS1 RNA is repressed in tumor relative to normal tissue. In most cancer types EPAS1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and LUAD are the cancer types where EPAS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPAS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.498	<.001	11	view →
LUSC	Female	II,III,IV	−3.754	<.001	9	view →
LUAD	Female	III,IV	−2.957	<.001	9	view →
HNSC	All	III,IV	+0.958	<.001	9	view →
THCA	All	II,III,IV	−0.933	<.001	9	view →
KICH	Male	II,III,IV	−1.771	<.001	8	view →
KIRP	Male	All	−1.771	<.001	7	view →
BRCA	All	All	−1.609	<.001	6	view →
KIRC	All	All	+0.665	<.001	5	view →
UCEC	All	All	−1.737	<.001	2	view →
READ	Female	All	−0.605	.023	2	view →
STAD	Male	II,III,IV	+0.585	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EPAS1–COAD

Open the COAD breakdown →