EPAS1

Across TCGA patient cohorts, EPAS1 mutation is significantly associated with the RNA expression of many other genes, with 5,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPAS1-associated genes across cancer lineages are DBNDD1, PTTG1, and SFXN1. Each is linked with EPAS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPAS1-to-partner and partner-to-EPAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBNDD1 grouped by EPAS1-low versus EPAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPAS1→partner) and Y-score (partner→EPAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DBNDD1 →	+0.399	+1.887	.006	<.001	3	4
SKCM	PTTG1 →	+0.775	+3.465	.001	.003	3	3
UCEC	SFXN1 →	+0.503	+1.544	<.001	<.001	3	3
UCEC	CDT1 →	+0.792	+2.317	<.001	<.001	3	3
UCEC	DFFB →	+0.400	+2.273	<.001	<.001	3	3
UCEC	PDIK1L →	+0.427	+1.898	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,189 associations by consensus.

DBNDD1 by EPAS1 expression — UCEC

Explore this box plot interactively →