EP300-AS1

Across TCGA pan-cancer cohorts, EP300-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EP300-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EP300-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated EP300-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, ACC, and LGG are the cancer types where EP300-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.790	0.652	<.001	76	view →
ACC	DFS	Median	All	0.420	0.736	<.001	52	view →
LGG	DFS	Median	All	0.776	0.880	<.001	37	view →
THCA	OS	Median	II,III,IV	0.954	0.996	.002	27	view →
LUAD	DFS	Quartile	All	0.841	0.576	<.001	23	view →
READ	OS	Quartile	All	0.970	0.457	.008	17	view →
STAD	OS	Quartile	III,IV	0.579	0.221	.011	16	view →
ESCA	OS	Median	III,IV	0.556	0.321	.016	9	view →
KIRP	DFS	Median	IV	0.042	0.620	.026	7	view →
KIRC	DFS	Quartile	All	0.859	0.742	.039	4	view →
KICH	OS	Median	III,IV	0.468	0.900	.016	4	view →
MESO	DFS	Median	All	0.300	0.422	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EP300-AS1–HNSC (DFS)

Open the HNSC breakdown →