EP300-AS1

Across TCGA pan-cancer cohorts, EP300-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of EP300-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where EP300-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types EP300-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and HNSC are the cancer types where EP300-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EP300-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−2.133	<.001	11	view →
LUSC	Male	II,III,IV	−1.580	<.001	8	view →
HNSC	Male	II,III,IV	−0.645	<.001	8	view →
THCA	All	II,III,IV	−0.591	<.001	8	view →
KIRC	All	II,III,IV	+0.373	<.001	8	view →
BRCA	All	II,III,IV	+0.342	.001	4	view →
BLCA	Male	All	+0.676	.039	2	view →
PRAD	All	All	+0.345	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

EP300-AS1–LUAD

Open the LUAD breakdown →