Q-omics provides the consensus-scored EP300-AS1 profile across patient tissues and cancer cell-line models. EP300-AS1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, EP300-AS1 is differentially expressed in 8, with the highest sampling consensus in LUAD. Additionally, EP300-AS1 RNA expression shows 19,636 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight HNSC, LUAD, and UVM as cancer lineages where EP300-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for EP300-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes EP300-AS1 survival associations across molecular data types. EP300-AS1 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible EP300-AS1 RNA expression–survival associations across cancer types. High EP300-AS1 expression shows unfavorable associations in ACC, LGG and THCA, but favorable associations in HNSC, LUAD and READ. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for EP300-AS1 RNA expression.
This table summarizes EP300-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for EP300-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. EP300-AS1 shows lower tumor expression in LUAD, LUSC, HNSC and THCA and higher tumor expression in KIRC and BRCA. The LUAD box plot shows higher EP300-AS1 RNA expression in normal versus tumor tissue (log2 FC = −2.133, t-test p < 0.001).
This table shows molecular features associated with EP300-AS1 in patient tissues and cancer cell lines. In patient samples, EP300-AS1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
