ENPP6

Across TCGA patient cohorts, ENPP6 mutation is significantly associated with the RNA expression of many other genes, with 1,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP6-associated genes across cancer lineages are MIR3122, RN7SL415P, and MIR7-3. Each is linked with ENPP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPP6-to-partner and partner-to-ENPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3122 grouped by ENPP6-low versus ENPP6-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP6→partner) and Y-score (partner→ENPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR3122 →	+0.908	+4.332	<.001	.002	3	3
CESC	RN7SL415P →	+0.105	+4.812	<.001	.006	3	3
CESC	MIR7-3 →	+0.275	+5.342	<.001	.002	3	2
READ	ANKRD20A6P →	+0.224	+4.341	<.001	.007	3	2
COAD	GAPDHP30 →	+0.146	+3.992	.004	.001	3	2
LUAD	MIR298 →	+0.476	+3.760	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,689 associations by consensus.

MIR3122 by ENPP6 expression — READ

Explore this box plot interactively →