ENPP6

Across TCGA pan-cancer cohorts, ENPP6 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ENPP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ENPP6 RNA is repressed in tumor relative to normal tissue. In most cancer types ENPP6 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where ENPP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENPP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−2.591	<.001	12	view →
COAD	Female	III,IV	−1.356	<.001	12	view →
KIRP	Female	II,III,IV	−4.572	<.001	11	view →
BLCA	Male	All	−1.719	<.001	10	view →
KICH	Female	II,III,IV	−3.017	<.001	9	view →
LUAD	Female	III,IV	−0.463	<.001	9	view →
BRCA	Female	II,III,IV	−0.701	<.001	6	view →
THCA	All	All	−0.253	<.001	6	view →
READ	All	All	−0.992	<.001	5	view →
UCEC	All	All	−0.790	.005	4	view →
STAD	Male	All	−0.428	.004	3	view →
HNSC	Male	All	−0.314	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ENPP6–KIRC

Open the KIRC breakdown →