ENPP4

Across TCGA cell cohorts, ENPP4 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENPP4-associated genes across cancer lineages are MYOD1, IFNA7, and IFNA4. Each is linked with ENPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP4-to-partner and partner-to-ENPP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by ENPP4-low versus ENPP4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP4→partner) and Y-score (partner→ENPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IFNA7 →	+0.034	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IFNA4 →	+0.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	MT1HL1 →	+0.560	+4.922	<.001	.009	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1
SKIN	FUT6 →	+0.103	+3.426	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MYOD1 by ENPP4 expression — BLOOD_Leukemia

Explore this box plot interactively →