ENPP4

Across TCGA pan-cancer cohorts, ENPP4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ENPP4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ENPP4 RNA is repressed in tumor relative to normal tissue. In most cancer types ENPP4 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and HNSC are the cancer types where ENPP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENPP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−3.115	<.001	9	view →
LUAD	Female	III,IV	−1.181	<.001	9	view →
HNSC	Male	All	−1.541	<.001	8	view →
THCA	Male	All	−0.601	<.001	7	view →
KICH	All	All	−0.890	<.001	6	view →
LIHC	Female	All	+0.951	<.001	5	view →
COAD	Female	All	−0.538	.007	4	view →
CHOL	All	All	+1.596	<.001	3	view →
READ	All	All	−0.585	.008	2	view →
KIRP	Male	All	−0.555	.001	2	view →
KIRC	All	III,IV	−0.366	.030	2	view →
BLCA	Male	III,IV	−1.237	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ENPP4–LUSC

Open the LUSC breakdown →