Q-omics provides the consensus-scored ENOX2 profile across patient tissues and cancer cell-line models. ENOX2 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ENOX2 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, ENOX2 RNA expression shows 19,273 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, HNSC, and UVM as cancer lineages where ENOX2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ENOX2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ENOX2 survival associations across molecular data types. ENOX2 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (8) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ENOX2 RNA expression–survival associations across cancer types. High ENOX2 expression shows unfavorable associations in LGG, UVM and COAD, but favorable associations in KIRC, ACC and SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ENOX2 RNA expression.
This table summarizes ENOX2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for ENOX2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ENOX2 shows lower tumor expression in THCA and higher tumor expression in HNSC, COAD, LIHC, STAD and KICH. The HNSC box plot shows higher ENOX2 RNA expression in tumor versus normal tissue (log2 FC = +1.367, t-test p < 0.001).
This table shows molecular features associated with ENOX2 in patient tissues and cancer cell lines. In patient samples, ENOX2 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ENOX2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
