EMCN

Across TCGA patient cohorts, EMCN mutation is significantly associated with the RNA expression of many other genes, with 520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMCN-associated genes across cancer lineages are MTND4P28, TAF9, and CENPH. Each is linked with EMCN in more than 2 cancer types. Because this analysis shows association rather than direction, both EMCN-to-partner and partner-to-EMCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4P28 grouped by EMCN-low versus EMCN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMCN→partner) and Y-score (partner→EMCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTND4P28 →	+0.101	+4.612	<.001	.006	3	3
UCEC	TAF9 →	+0.601	+3.343	<.001	.005	3	2
UCEC	CENPH →	+0.636	+2.592	.002	.006	3	2
UCEC	SKA1 →	+0.747	+3.346	<.001	.005	3	2
UCEC	CDT1 →	+0.884	+3.606	<.001	.001	3	2
COAD	RNU6-147P →	+0.858	+5.212	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 520 associations by consensus.

MTND4P28 by EMCN expression — LUAD

Explore this box plot interactively →