EMCN

Across TCGA pan-cancer cohorts, EMCN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EMCN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EMCN RNA is repressed in tumor relative to normal tissue. In most cancer types EMCN is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where EMCN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EMCN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	−1.537	<.001	12	view →
KICH	Male	III,IV	−4.202	<.001	11	view →
KIRP	Male	All	−4.004	<.001	11	view →
BLCA	Male	All	−2.074	<.001	11	view →
THCA	All	IV	−1.945	<.001	11	view →
LUSC	Female	II,III,IV	−3.825	<.001	9	view →
LUAD	Female	III,IV	−3.202	<.001	9	view →
LIHC	All	II,III,IV	+0.994	<.001	8	view →
HNSC	Male	All	−0.964	<.001	8	view →
COAD	Female	II,III,IV	−0.949	<.001	8	view →
UCEC	All	All	−3.623	<.001	6	view →
BRCA	All	II,III,IV	−1.726	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EMCN–KIRC

Open the KIRC breakdown →