EMCN

Across TCGA cell cohorts, EMCN mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EMCN-associated genes across cancer lineages are PTH2R, MSGN1, and PGLYRP3. Each is linked with EMCN in more than 1 cancer types. Because this analysis shows association rather than direction, both EMCN-to-partner and partner-to-EMCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH2R grouped by EMCN-low versus EMCN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMCN→partner) and Y-score (partner→EMCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH2R →	+1.381	+3.453	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.126	+4.345	<.001	<.001	3	1
LARGE_INTESTINE	PGLYRP3 →	+0.608	+3.854	<.001	.006	3	1
LARGE_INTESTINE	CFAP47 →	+0.225	+3.453	.002	.009	3	1
LARGE_INTESTINE	COX7B2 →	+0.542	+3.878	.002	.003	3	1
LARGE_INTESTINE	FREM3 →	+0.181	+4.376	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PTH2R by EMCN expression — LARGE_INTESTINE

Explore this box plot interactively →