ELL2

Across TCGA patient cohorts, ELL2 mutation is significantly associated with the RNA expression of many other genes, with 3,904 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELL2-associated genes across cancer lineages are NDUFS3, ATF4P3, and LINC01777. Each is linked with ELL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ELL2-to-partner and partner-to-ELL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFS3 grouped by ELL2-low versus ELL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELL2→partner) and Y-score (partner→ELL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFS3 →	+0.262	+3.711	.005	<.001	3	3
UCEC	ATF4P3 →	+0.369	+2.369	<.001	<.001	3	3
LIHC	LINC01777 →	+0.399	+4.153	<.001	.004	3	3
UCEC	CCT8 →	+0.375	+2.255	.003	.001	3	3
UCEC	BOLA3 →	+0.346	+1.896	.003	.004	3	3
UCEC	CHCHD4 →	+0.364	+2.860	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,904 associations by consensus.

NDUFS3 by ELL2 expression — UCEC

Explore this box plot interactively →