ELL2

Across TCGA pan-cancer cohorts, ELL2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ELL2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ELL2 RNA is repressed in tumor relative to normal tissue. In most cancer types ELL2 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

THCA, KIRC, and STAD are the cancer types where ELL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ELL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.230	<.001	9	view →
KIRC	Male	IV	+0.984	<.001	8	view →
STAD	All	All	−0.886	<.001	8	view →
UCEC	All	II,III,IV	−1.380	<.001	6	view →
KIRP	All	II,III,IV	−0.740	.007	6	view →
KICH	Female	All	−1.657	<.001	4	view →
CHOL	All	All	−1.389	.003	2	view →
BLCA	All	All	−0.645	.046	2	view →
PRAD	All	All	+0.302	.012	2	view →
BRCA	All	All	−0.234	.024	2	view →
READ	Female	All	−0.714	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ELL2–THCA

Open the THCA breakdown →