ELL

Across TCGA patient cohorts, ELL mutation is significantly associated with the RNA expression of many other genes, with 1,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELL-associated genes across cancer lineages are MTND6P16, TLE6, and YBEY. Each is linked with ELL in more than 2 cancer types. Because this analysis shows association rather than direction, both ELL-to-partner and partner-to-ELL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P16 grouped by ELL-low versus ELL-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELL→partner) and Y-score (partner→ELL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTND6P16 →	+0.088	+5.268	<.001	.003	3	3
COAD	TLE6 →	+0.502	+3.351	.008	.005	3	2
UCEC	YBEY →	+0.385	+1.895	.007	.001	3	2
UCEC	SPNS2 →	+0.807	+2.016	.001	.005	3	2
UCEC	SNAI3 →	+0.394	+2.158	.001	.009	3	2
UCEC	EMID1 →	-1.086	-1.863	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,193 associations by consensus.

MTND6P16 by ELL expression — BRCA

Explore this box plot interactively →