ELK3

Across TCGA patient cohorts, ELK3 mutation is significantly associated with the RNA expression of many other genes, with 4,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELK3-associated genes across cancer lineages are RN7SL447P, RNU7-62P, and MTATP6P30. Each is linked with ELK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELK3-to-partner and partner-to-ELK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL447P grouped by ELK3-low versus ELK3-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELK3→partner) and Y-score (partner→ELK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RN7SL447P →	+0.474	+5.149	<.001	.007	3	2
BRCA	RNU7-62P →	+0.666	+7.731	<.001	.009	3	2
HNSC	MTATP6P30 →	+0.089	+7.954	<.001	.008	3	2
HNSC	RNU7-34P →	+0.633	+7.954	<.001	.008	3	2
STAD	MIR4667 →	+0.665	+4.440	<.001	.006	3	2
HNSC	USP9YP22 →	+0.194	+7.954	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,072 associations by consensus.

RN7SL447P by ELK3 expression — GBM

Explore this box plot interactively →