ELK3

Across TCGA pan-cancer cohorts, ELK3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ELK3 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ELK3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ELK3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

KIRP, KIRC, and MESO are the cancer types where ELK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.751	0.930	.001	84	view →
KIRC	OS	Tertile	All	0.740	0.551	<.001	81	view →
MESO	OS	Tertile	All	0.254	0.585	<.001	63	view →
LUSC	OS	Tertile	All	0.712	0.828	.002	57	view →
LGG	OS	Median	All	0.360	0.550	<.001	54	view →
ESCA	DFS	Tertile	III,IV	0.597	0.299	<.001	45	view →
STAD	DFS	Quartile	All	0.306	0.531	.015	44	view →
PAAD	OS	Quartile	All	0.457	0.786	<.001	31	view →
BLCA	DFS	Quartile	II,III,IV	0.511	0.632	.012	30	view →
UVM	DFS	Quartile	III,IV	0.170	0.814	.001	30	view →
SKCM	OS	Quartile	III,IV	0.531	0.214	.001	26	view →
LUAD	DFS	Tertile	II,III,IV	0.535	0.761	.013	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ELK3–KIRP (DFS)

Open the KIRP breakdown →