EIF4E1B

Across TCGA patient cohorts, EIF4E1B mutation is significantly associated with the RNA expression of many other genes, with 335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E1B-associated genes across cancer lineages are SLC25A15P4, SERF1AP1, and HMX2. Each is linked with EIF4E1B in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E1B-to-partner and partner-to-EIF4E1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A15P4 grouped by EIF4E1B-low versus EIF4E1B-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E1B→partner) and Y-score (partner→EIF4E1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC25A15P4 →	+0.359	+5.435	<.001	.005	3	2
STAD	SERF1AP1 →	+0.400	+5.366	<.001	.005	3	2
UCEC	HMX2 →	+1.194	+2.595	<.001	.006	3	2
UCEC	HMGN1P20 →	+0.178	+2.640	<.001	.003	3	2
LIHC	RN7SL680P →	+0.122	+5.902	<.001	.001	3	1
UCEC	SQSTM1P1 →	+0.061	+2.709	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

SLC25A15P4 by EIF4E1B expression — HNSC

Explore this box plot interactively →