EIF4E1B

Across TCGA pan-cancer cohorts, EIF4E1B RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EIF4E1B’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where EIF4E1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF4E1B is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

BRCA, COAD, and KIRC are the cancer types where EIF4E1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF4E1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.187	<.001	6	view →
COAD	All	All	−0.007	.001	6	view →
KIRC	Male	All	−0.013	<.001	3	view →
LUAD	All	All	+0.207	.014	1	view →
KICH	All	All	−0.015	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

EIF4E1B–BRCA

Open the BRCA breakdown →