EIF4E1B

Across TCGA pan-cancer cohorts, EIF4E1B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated EIF4E1B data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF4E1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EIF4E1B expression acts as an unfavorable survival marker, although some lineages such as CESC and LGG show a favorable association.

UCEC, CESC, and LIHC are the cancer types where EIF4E1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.471	0.766	.002	108	view →
CESC	OS	Tertile	All	0.890	0.760	.008	76	view →
LIHC	OS	Tertile	III,IV	0.326	0.651	.001	63	view →
KICH	DFS	Tertile	III,IV	0.256	0.881	.003	52	view →
LGG	OS	Median	All	0.929	0.862	.001	35	view →
CHOL	DFS	Tertile	All	0.758	0.131	<.001	27	view →
MESO	OS	Quartile	IV	0.834	0.276	.012	16	view →
KIRC	DFS	Quartile	All	0.436	0.680	.006	12	view →
THYM	DFS	Tertile	All	0.743	0.931	.012	10	view →
SARC	OS	Tertile	All	0.576	0.762	.021	9	view →
ACC	DFS	Quartile	II,III,IV	0.707	0.375	.019	7	view →
PAAD	DFS	Quartile	II,III,IV	0.358	0.571	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

EIF4E1B–UCEC (OS)

Open the UCEC breakdown →