EIF4E1B

Across TCGA patient cohorts, EIF4E1B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E1B-associated genes across cancer lineages are GAPDH, PCNA, and PKC-a_pS657. Each is linked with EIF4E1B in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E1B-to-partner and partner-to-EIF4E1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by EIF4E1B-low versus EIF4E1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E1B→partner) and Y-score (partner→EIF4E1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.607	+3.169	.030	.019	3	2
UCEC	PCNA →	+0.330	+2.999	.003	.035	3	1
UCEC	PKC-a_pS657 →	-0.510	-2.999	.010	.035	3	1
UCEC	PKC-b-II_pS660 →	-0.421	-3.169	.003	.019	3	1
UCEC	SCD →	+0.122	+3.009	.034	.019	3	1
UCEC	STAT3_pY705 →	-0.462	-2.990	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by EIF4E1B expression — UCEC

Explore this box plot interactively →