EIF4E1B

Across TCGA cell cohorts, EIF4E1B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,115 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF4E1B-associated GO terms across cancer lineages are Regulation of nuclear cell cycle DNA replication, Negative regulation of bone mineralization involved in bone maturation, and Response to triglyceride. Each is linked with EIF4E1B in more than 5 cancer types. Because this analysis shows association rather than direction, both EIF4E1B-to-partner and partner-to-EIF4E1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear cell cycle DNA replication grouped by EIF4E1B-low versus EIF4E1B-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E1B→partner) and Y-score (partner→EIF4E1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of nuclear cell cycle DNA replication →	+0.059	+0.114	.007	.004	2	6
OVARY	Negative regulation of bone mineralization involved in bone maturation →	-0.980	-0.140	<.001	<.001	3	5
BONE	Response to triglyceride →	-0.104	-0.019	.003	.006	2	5
BLOOD_Lymphoma	Regulation of vitamin metabolic process →	-0.077	-0.114	.004	.004	3	4
OVARY	Regulation of calcium ion transport into cytosol →	-0.178	-0.190	<.001	.006	3	4
OVARY	Positive regulation of double-strand break repair →	+0.057	+0.142	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

Regulation of nuclear cell cycle DNA replication by EIF4E1B expression — BLOOD_Lymphoma

Explore this box plot interactively →