EIF2S3

Across TCGA patient cohorts, EIF2S3 mutation is significantly associated with the RNA expression of many other genes, with 972 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2S3-associated genes across cancer lineages are RN7SKP85, MRPS16P1, and LINC00433. Each is linked with EIF2S3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2S3-to-partner and partner-to-EIF2S3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP85 grouped by EIF2S3-low versus EIF2S3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S3→partner) and Y-score (partner→EIF2S3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP85 →	+0.170	+5.762	<.001	<.001	3	2
BLCA	MRPS16P1 →	+0.074	+5.147	<.001	.003	3	2
BLCA	LINC00433 →	+0.126	+5.618	<.001	.002	3	2
BLCA	RN7SL91P →	+0.110	+5.814	<.001	.001	3	2
BLCA	OR7E163P →	+0.071	+5.162	<.001	.001	3	2
LUSC	RN7SKP267 →	+0.191	+4.984	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 972 associations by consensus.

RN7SKP85 by EIF2S3 expression — BLCA

Explore this box plot interactively →