EIF2S3

Across TCGA pan-cancer cohorts, EIF2S3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated EIF2S3 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher EIF2S3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF2S3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

KIRP, ACC, and LIHC are the cancer types where EIF2S3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.767	0.934	<.001	126	view →
ACC	DFS	Median	All	0.167	0.644	<.001	84	view →
LIHC	OS	Median	All	0.698	0.853	<.001	68	view →
KIRC	DFS	Tertile	All	0.746	0.513	<.001	67	view →
OV	OS	Tertile	II,III,IV	0.885	0.792	.007	62	view →
LUAD	OS	Tertile	All	0.606	0.750	<.001	58	view →
CESC	DFS	Median	All	0.760	0.879	.001	44	view →
HNSC	OS	Tertile	II,III,IV	0.550	0.703	.001	42	view →
MESO	DFS	Quartile	All	0.244	0.481	.001	39	view →
KICH	DFS	Quartile	All	0.565	1.000	.002	36	view →
PAAD	OS	Quartile	II,III,IV	0.412	0.763	.003	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

EIF2S3–KIRP (DFS)

Open the KIRP breakdown →