EIF2S3

Across TCGA pan-cancer cohorts, EIF2S3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EIF2S3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EIF2S3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF2S3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where EIF2S3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF2S3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.218	<.001	11	view →
KIRC	All	IV	+0.540	<.001	11	view →
HNSC	Male	All	+0.537	<.001	11	view →
LIHC	Male	II,III,IV	+1.173	<.001	9	view →
LUAD	Male	II,III,IV	+1.049	<.001	8	view →
STAD	Male	II,III,IV	+0.875	<.001	6	view →
BRCA	All	II,III,IV	+0.330	<.001	6	view →
CHOL	Female	All	+2.599	<.001	5	view →
LUSC	Male	All	+0.688	<.001	5	view →
KICH	Female	II,III,IV	−1.278	<.001	4	view →
BLCA	Male	All	+0.317	.018	4	view →
READ	All	All	+1.017	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EIF2S3–COAD

Open the COAD breakdown →