EIF2S3

Across TCGA patient cohorts, EIF2S3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2S3-associated genes across cancer lineages are ER-alpha_pS118, ERK2, and ACC_pS79. Each is linked with EIF2S3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2S3-to-partner and partner-to-EIF2S3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by EIF2S3-low versus EIF2S3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S3→partner) and Y-score (partner→EIF2S3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	+0.412	+3.013	.008	.018	3	1
UCEC	ERK2 →	+0.220	+3.169	.008	.018	3	1
UCEC	ACC_pS79 →	+0.328	+3.009	.030	.019	3	1
UCEC	GATA6 →	-0.150	-2.108	.026	.018	3	1
UCEC	Heregulin →	-0.146	-3.156	.006	.018	3	1
UCEC	HSP70 →	-0.379	-3.312	.031	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ER-alpha_pS118 by EIF2S3 expression — UCEC

Explore this box plot interactively →