EIF2S3

Across TCGA cell cohorts, EIF2S3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,169 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EIF2S3-associated GO terms across cancer lineages are Lagging strand elongation, Base-excision repair, gap-filling, and Growth hormone secretion. Each is linked with EIF2S3 in more than 13 cancer types. Because this analysis shows association rather than direction, both EIF2S3-to-partner and partner-to-EIF2S3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lagging strand elongation grouped by EIF2S3-low versus EIF2S3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S3→partner) and Y-score (partner→EIF2S3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Lagging strand elongation →	+0.260	+0.835	.005	<.001	3	14
BONE	Base-excision repair, gap-filling →	+0.090	+0.599	.001	<.001	3	10
URINARY_TRACT	Growth hormone secretion →	+0.101	+0.822	<.001	<.001	3	10
LARGE_INTESTINE	IMP biosynthetic process →	+0.130	+0.872	.002	<.001	3	9
PANCREAS	Ribosomal protein import into nucleus →	+0.113	+1.187	<.001	<.001	3	9
SOFT_TISSUE	Muscle filament sliding →	-0.236	-0.744	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,169 associations by consensus.

Lagging strand elongation by EIF2S3 expression — PANCREAS

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