EIF2S1

Across TCGA patient cohorts, EIF2S1 mutation is significantly associated with the RNA expression of many other genes, with 2,083 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2S1-associated genes across cancer lineages are RNA5SP131, NPLP1, and RN7SL248P. Each is linked with EIF2S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2S1-to-partner and partner-to-EIF2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP131 grouped by EIF2S1-low versus EIF2S1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2S1→partner) and Y-score (partner→EIF2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP131 →	+0.263	+5.722	<.001	.001	3	2
COAD	NPLP1 →	+0.257	+5.080	<.001	.008	3	2
UCEC	RN7SL248P →	+0.067	+3.400	<.001	.003	3	2
UCEC	RNU6-628P →	+0.464	+2.236	<.001	.002	3	2
CESC	NEUROD6 →	+0.015	+4.812	.002	.006	3	1
CESC	LINC00314 →	+0.045	+4.669	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,083 associations by consensus.

RNA5SP131 by EIF2S1 expression — BLCA

Explore this box plot interactively →