EIF2D

Across TCGA patient cohorts, EIF2D mutation is significantly associated with the RNA expression of many other genes, with 1,967 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2D-associated genes across cancer lineages are IGHD1-1, TCEA1P4, and MTND4LP20. Each is linked with EIF2D in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2D-to-partner and partner-to-EIF2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD1-1 grouped by EIF2D-low versus EIF2D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2D→partner) and Y-score (partner→EIF2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IGHD1-1 →	+0.929	+2.333	.001	.003	3	2
SKCM	TCEA1P4 →	+0.254	+3.497	.006	.002	3	2
CESC	MTND4LP20 →	+0.168	+7.164	<.001	<.001	3	2
LUAD	RNY3 →	+2.363	+4.631	<.001	.008	3	2
LUAD	RN7SL147P →	+0.766	+4.218	<.001	.009	3	2
LUAD	MIR1299 →	+0.807	+5.157	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,967 associations by consensus.

IGHD1-1 by EIF2D expression — SKCM

Explore this box plot interactively →