EIF2D

Across TCGA pan-cancer cohorts, EIF2D RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated EIF2D data layer compared with 1 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher EIF2D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF2D expression acts as an unfavorable survival marker, although some lineages such as MESO and UVM show a favorable association.

KIRP, LIHC, and KICH are the cancer types where EIF2D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.855	0.960	<.001	91	view →
LIHC	OS	Median	All	0.695	0.862	<.001	57	view →
KICH	OS	Median	II,III,IV	0.757	1.000	.005	56	view →
ACC	DFS	Tertile	All	0.257	0.704	.004	35	view →
CESC	DFS	Tertile	All	0.712	0.886	<.001	32	view →
MESO	OS	Median	II,III,IV	0.499	0.291	.006	30	view →
BLCA	OS	Quartile	All	0.428	0.739	.006	22	view →
UVM	DFS	Tertile	II,III,IV	0.822	0.375	<.001	21	view →
READ	OS	Median	II,III,IV	0.982	0.841	.004	17	view →
LGG	DFS	Median	All	0.799	0.863	.008	13	view →
UCEC	OS	Tertile	III,IV	0.668	0.430	.026	12	view →
DLBC	DFS	Quartile	All	0.469	0.984	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

EIF2D–KIRP (DFS)

Open the KIRP breakdown →