EIF2D

Across TCGA pan-cancer cohorts, EIF2D RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EIF2D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EIF2D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF2D is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where EIF2D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF2D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.496	<.001	12	view →
THCA	Male	IV	−0.456	<.001	10	view →
LIHC	Male	II,III,IV	+1.401	<.001	9	view →
KIRP	All	II,III,IV	+0.432	<.001	8	view →
KICH	Female	II,III,IV	−1.331	<.001	7	view →
UCEC	All	All	−0.620	<.001	6	view →
COAD	All	II,III,IV	+0.394	<.001	6	view →
CHOL	Male	All	+1.896	<.001	5	view →
BRCA	Female	All	−0.286	<.001	4	view →
PRAD	All	All	+0.163	.039	2	view →
BLCA	Female	III,IV	+0.477	.017	1	view →
BLCA	Male	III,IV	−0.385	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EIF2D–KIRC

Open the KIRC breakdown →