EIF2D

Across TCGA patient cohorts, EIF2D mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2D-associated genes across cancer lineages are PCNA, Rad50, and Annexin-1. Each is linked with EIF2D in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2D-to-partner and partner-to-EIF2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by EIF2D-low versus EIF2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2D→partner) and Y-score (partner→EIF2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.213	+2.000	.012	.030	3	2
UCEC	Rad50 →	-0.231	-2.321	.015	.034	3	2
UCEC	Annexin-1 →	+0.711	+3.604	<.001	.001	3	2
UCEC	ATM →	-0.548	-1.986	.002	.029	3	2
UCEC	EGFR_pY1173 →	-0.085	-3.169	.006	.018	3	1
UCEC	eIF4E →	+0.236	+2.502	.004	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PCNA by EIF2D expression — UCEC

Explore this box plot interactively →