EIF2D

Across TCGA cell cohorts, EIF2D RNA expression is significantly associated with the go_rna of many other GO terms, with 2,063 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF2D-associated GO terms across cancer lineages are IRES-dependent viral translational initiation, Viral translation, and Heme biosynthetic process. Each is linked with EIF2D in more than 14 cancer types. Because this analysis shows association rather than direction, both EIF2D-to-partner and partner-to-EIF2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRES-dependent viral translational initiation grouped by EIF2D-low versus EIF2D-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2D→partner) and Y-score (partner→EIF2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IRES-dependent viral translational initiation →	+0.099	+0.571	<.001	<.001	3	15
URINARY_TRACT	Viral translation →	+0.078	+0.406	.004	.007	2	12
PANCREAS	Heme biosynthetic process →	+0.099	+0.540	<.001	.001	3	10
BLOOD_Lymphoma	Establishment of protein localization to endoplasmic reticulum membrane →	+0.114	+0.622	<.001	<.001	3	10
PANCREAS	Tetrapyrrole biosynthetic process →	+0.093	+0.439	<.001	.005	3	8
PANCREAS	Porphyrin-containing compound biosynthetic process →	+0.093	+0.439	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,063 associations by consensus.

IRES-dependent viral translational initiation by EIF2D expression — KIDNEY

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