EIF2AK1

Across TCGA patient cohorts, EIF2AK1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2AK1-associated genes across cancer lineages are Annexin-1, ASNS, and Caspase-7-cleavedD198. Each is linked with EIF2AK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2AK1-to-partner and partner-to-EIF2AK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by EIF2AK1-low versus EIF2AK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK1→partner) and Y-score (partner→EIF2AK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.613	+2.019	<.001	.005	3	2
UCEC	ASNS →	+0.278	+1.584	.024	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.554	+2.019	.006	.005	3	2
UCEC	EGFR →	-0.159	-1.848	.003	.049	3	1
UCEC	eIF4E →	+0.183	+2.713	.010	.003	3	1
UCEC	A-Raf_pS299 →	-0.164	-2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Annexin-1 by EIF2AK1 expression — UCEC

Explore this box plot interactively →